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KMID : 0378019840270070079
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New Medical Journal
1984 Volume.27 No. 7 p.79 ~ p.84
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The Influence of Berberine on the Vasopressor Response to Ketamine in Rabbits
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Abstract
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An increasing interest in ketamine has resulted from the rapid onset of hypnosis and analgesia after I.M. or I.V. injection and the lack of cardiovascular or respiratory depression.
The dissociative anesthetics, ketamine, produces an elevation in mean arterial blood pressure which is secondary to an increase in heart rate and cardiac output. But the circulatory effect on ketamine don´t appear to be a predominant mechanism. The cardiovascular effect of anesthesia with ketamine is quite acceptable in patients with healthy hearts Since cardiac output is increased with only small changes in peripheral resistant (25%), it would appear to be a desirable agent , for use in the pressure of hypovolemia, hemorrhage or shock. But it should be administrated with caution to those with severe myocardiac, coronary and hypertensive disease. Nevertheless, in few cases, ketamine has been frequently increased in arterial blood pressure.
For this reason, this experiment was carried out in order to clarify the role of ketamine on the vasopressure response in rabbits anesthetized with secobarbital. The responses on the arterial blood pressure were observed the interaction with ketamine and berberine.
The results of this experiment were as follows;
1) Administration of single ketamine (2mg/kg) did not show any significant difference in the arterial blood pressure compared with that of control group. In the rabbit pretreated with epinephrine (1μg/kg, 2μg/kg and 4μg/kg), the pressure responses to ketamine were significantly increased in comparison with that of administration group of single epinephrine.
2) On the blood pressure of rabbits pretreated with berberine (2mg/kg, 5mg/kg and l0mg/ kg), the depressor responses to ketamine (2mg/kg) were significantly increased in comparison with that of administration group of single berberine.
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